Agile Pulse In Vivo系統能有效增強免役反應并縮短免役接種程序，從而極大提高您的實驗效率。

Agile Pulse In Vivo系統廣泛應用于：

皮下DNA疫苗接種

肌肉DNA疫苗接種

肌肉DNA疫苗接種

Drug導入

特點：

方波

多重方波

電阻/電擊脈沖監控

實驗日志存儲

無限量自定義程序存貯

遠程控制

電穿孔應用：

真核細胞

活體（活體電極）

皮下接種（針形矩陣電極）

肌肉接種（針形矩陣電極）

技術參數：

用戶界面：觸摸屏

電壓：50 - 1000 v

脈沖時間：5 μs - 10 ms

脈沖間隔時間：20 μs - 1 s

數據輸出：USB盤

產品尺寸（長x 寬x高）：12.6 x 7.9 x 15.7 in

重量：25 lbs

工作溫度：10° - 40° C

輸入電壓：100 - 250 VAC

已發表文獻：

Bongard N, Lapuente D, Windmann S, Dittmer U, Tenbusch M, Bayer, W. Interference of Retroviral Envelope with Vaccine-Induced CD8+ T Cell Responses is Relieved by Co-Administration of Cytokine-Encoding Vectors. Retrovirology. 2017;14: 28.

Eyquem J, et al. Targeting a CAR to the TRAC Locus with CRISPR/Cas9 Enhances Tumour Rejection. Nature. 2017;543: 113-117.

Juillerat A, et al. An Oxygen Sensitive Self-Decision Making Engineered CAR T-Cell. Sci Rep. 2017 Jan 20;7: 39833.

Denies S, et al. Evaluation of a Xenogeneic Vascular Endothelial Growth Factor-2 vaccine in Two Preclinical Metastatic Tumor Models in Mice. Cancer Immunol Immunother. 2017 Dec;66(12): 1545-1555.

Juillerat A, et al. Design of Chimeric Antigen Receptors with Integrated Controllable Transient Functions. Sci Rep. 2016 Jan 11;6: 18950.

Peterson CW, et al. Long-Term Multi-Lineage Engraftment of Genome-Edited Hematopoietic Stem Cells after Autologous Transplantation in Nonhuman Primates. Blood. 2016 May 19;127(20): 2416-2426.

Hawksworth DJ, Ziemann R, Manoj S. Enhanced Immune Response Following DNA Immunization Through In Vivo Electroporation. Monoclon Antib IImmunodiagn Immunother. 2016 Jul 27;35(5): 239-244.

Juillerat A, et al. Design of chimeric antigen receptors with integrated controllable transient functions. Sci Rep. 2016 Jan 11;6: 18950.

Christopher W, et al, Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates. Blood. 2016;127: 2416-2426.

Wang L, et al. Evaluation of Candidate Vaccine Approaches for MERS-CoV. Nat Comm. 2015 Jul28;6:7 712.

Davtyan H, et al. BTX AgilePulse(TM) System is an Effective Electroporation Device for Intramuscular and Intradermal Delivery of DNA Vaccine. Curr Gene Ther. 2014;14(3): 190-199.

Daftarian MP, Vosoughi A, Lemmon V. Gene-Based Vaccination and Screening Methods to Develop Monoclonal Antibodies. Methods Mol Biol. 2014;1121: 337-346.

Johansson DX, Ljungberg K, Kakoulidou M, Liljestrom P. Intradermal Electroporation of Naked Replicon RNA Elicits Strong Immune Responses. PLoS One, 2012 Jan 4;7(1): e29732.

Lladser A, Ljungberg K, Tufvesson H, Tazzari M, Roos A, Quest FG, Kiessling R. Intradermal electroporation with a survivin DNA vaccine induces CTLs against a self-epitope, suppresses angiogenesis and confers long-term protection against mouse melanoma. Cancer Immunol Immunother. 2010 Jan;59(1): 81-92.

Lundberg K, Roos A-K, Pavlenko M, Wehrum D, Pisa P. A modified epitope identified for generation and monitoring of PSA-specific T cells in patients on early phases of PSA-based immunotherapeutic protocols. Vaccine. 2009 Mar 4;27(10): 1557-65.

Br?ve A, Halleng?rd D, Gudmundsdotter L, Stout R, Walters R, Wahren B, Hallermalm K. Late administration of plasmid DNA by intradermal electroporation efficiently boosts DNA-primed T and B cell responses to carcinoembryonic antigen. Vaccine. 2009 Jun 8;27(28): 3692-6.

Roos, A-K, Eriksson, F, Walters, D, Pisa, P, King, A. Optimization of skin electroporation in mice to increase tolerability of DNA vaccine delivery to patients. Molecular Therapy. 2009 Sep;17(9): 1637-42.